Kutki (Picrorrhiza kurroa)
Picrorhiza kurroa is a well-known herb in the Ayurvedic system of medicine and has traditionally been used to treat disorders of the liver and upper respiratory tract, reduce fevers, and to treat dyspepsia, chronic diarrhea, and scorpion sting. It is a small perennial herb from the Scrophulariaceae family, found in the Himalayan region.
Studies have shown this herb to have the following actions:-
Hepatoprotective: Kutki inhibits lipid oxidation, by lowering malondialdehyde (MDA) formation, and by maintaining high levels of glutathione (GSH) in the liver.
Prevent hepatic fat deposition: Kitki inhibits free fatty acids - induced lipid accumulation by attenuating the expression of fatty acid transport protein 5, sterol regulatory element binding protein 1 and stearoyl coa desaturase.
Hepatoproregenrative: Kutki stimulate the action of nucleolar polymerase A, that synthesis ribosomal protein and stimulates the regenerative ability of the liver (formation of new hepatocytes).
Anti-inflammatory and anti-fibrotic: Kutki blocks inflammation and fibrogenesis of liver by suppressing NF-κB transcriptional activation in HepG2 cells.
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